Das Lehrgebiet BioVT publiziert mit Partnern der Tanta University (Ägypten) und der Princess Nourah bint Abdulrahman University (Saudi Arabien) in der Zeitschrift "Marine Drugs" den Artikel “Insight into Fucoidan-based PEGylated PLGA Nanoparticles Encapsulating Methyl Anthranilic Acid: In Vitro Evaluation and In Vivo Anti-inflammatory Study”.
A potential fucoidan-based PEGylated PLGA nanoparticles (NPs) offering a proper deliv-21 ery of N-methyl anthranilic acid (MA, a model of hydrophobic anti-inflammatory drug) have been 22 developed via the formation of fucoidan aqueous coating surrounding PEGylated PLGA NPs. The 23 optimum formulation (FuP2) composed of fucoidan:m-PEG-PLGA (1:0.5 w/w) with particle size 24 (365±20.76 nm), zeta potential (-22.30±2.56 mV), % entrapment efficiency (85.45±7.41), drug loading 25 (51.36±4.75 μg/mg of NPs), % initial burst (47.91±5.89), and % cumulative release (102.79±6.89) has 26 been furtherly investigated for the anti-inflammatory in vivo study. This effect of FuP2 was assessed 27 in rats' carrageenan-induced acute inflammation model. The average weight of the paw edema was 28 significantly lowered (p≤0.05) by treatment with FuP2. Moreover, cyclooxygenase-2 and tumor ne-29 crosis factor-alpha immunostaining were decreased in FuP2 treated group compared to the other 30 groups. The levels of prostaglandin E2, nitric oxide, and malondialdehyde were significantly re-31 duced (p≤0.05) in the FuP2-treated group. A significant reduction (p≤0.05) in the expression of inter-32 leukins (IL-1β and IL-6) with an improvement of the histological findings of the paw tissues was 33 observed in the FuP2-treated group. Thus, fucoidan-based PEGylated PLGA–MA NPs are a prom-34 ising anti-inflammatory delivery system that can be applied for other similar drugs potentiating 35 their pharmacological and pharmacokinetic properties.
D.H. Abdelkader, E. Elekhnawy, W.A. Negm, T.A. El-Masry, M. Almukainzi, A. Zayed, R. Ulber; Insight into Fucoidan-based PEGylated PLGA Nanoparticles Encapsulating Methyl Anthranilic Acid: In Vitro Evaluation and In Vivo Anti-inflammatory Study; Marine Drugs (2022) im Druck