Aim of the research project is the systematic study of the fatigue behavior of high strength metal matrix composites in the high and very high cycle regime using an ultrasonic resonance testing system. Four particle reinforced aluminum matrix composites with different particle sizes and different particle volume fraction are investigated. For comparison, the pure aluminum alloy is included in the investigations. The experiments are carried out on a piezoelectric testing facility developed at the Department of Materials Science and Engineering at the University of Kaiserslautern with a test frequency of 20 kHz. To characterize the fatigue state high resolution electric, optical and thermometric measurement techniques are used. Additionally the generator power and the shape of the specimen displacement are used for the evaluation of cyclic deformation behavior. Characteristic fatigue stages are analyzed by light, scanning and transmission electron microscopy and μCT scans to establish a relationship between microstructural changes and physical measurements.